NTRK1 H604Y
Gene Variant Detail

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Gene NTRK1
Variant H604Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NTRK1 H604Y lies within the protein kinase domain of the Ntrk1 protein (UniProt.org). H604Y is a common Ntrk1 polymorphism (PMID: 20003389, PMID: 38531265), and is not transforming in culture, results in increased phosphorylation of Akt in combination with NTRK1 G613V in patient samples, and has been associated with resistance to NTRK inhibitors in cell culture (PMID: 38531265), but has not been individually biochemically characterized and therefore, its effect on Ntrk1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

NTRK1 mutant NTRK1 H604Y

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Transcript NM_002529.4
gDNA chr1:g.156879126C>T
cDNA c.1810C>T
Protein p.H604Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002529.4 chr1:g.156879126C>T c.1810C>T p.H604Y RefSeq GRCh38/hg38
NM_002529.3 chr1:g.156879126C>T c.1810C>T p.H604Y RefSeq GRCh38/hg38
NM_002529 chr1:g.156879126C>T c.1810C>T p.H604Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries