BRAF V600M
Gene Variant Detail

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Gene BRAF
Variant V600M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF V600M (previously reported as V599) lies within the activation segment of the kinase domain of the Braf protein (PMID: 15035987). V600M results in intermediate Braf kinase activity in cell culture in one study (PMID: 28783719), but Mek phosphorylation to similar levels of wild-type protein in another study (PMID: 26744778), and increases cell proliferation and cell viability in one of two cell lines in culture (PMID: 29533785), and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V600X BRAF V600M

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Transcript NM_004333.6
gDNA chr7:g.140753337C>T
cDNA c.1798G>A
Protein p.V600M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38
NM_004333 chr7:g.140753337C>T c.1798G>A p.V600M RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600M lung non-small cell carcinoma predicted - sensitive Vemurafenib Case Reports/Case Series Actionable In a Phase II trial, Zelboraf (vemurafenib) treatment resulted in a objective response rate of 44.8% (43/96), median duration of response of 6.4 months, median progression-free survival (PFS) of 5.2 months, and median overall survival of 10 months in non-small cell lung cancer patients with BRAF V600 mutations, with a PFS of 5.9 months in the patient harboring BRAF V600M (PMID: 31959346; NCT02304809). 31959346