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MAP2K1 P124S - Gene Variant Detail

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Gene MAP2K1
Variant P124S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MAP2K1 P124S lies within the protein kinase domain of the Map2k1 protein (UniProt.org). P124S results in increased Erk1/2 phosphorylation and confers resistance to Mek and Braf inhibitors (PMID: 19915144, PMID: 22197931) and an Egfr antibody (PMID: 33322618) in culture, but has similar induction of cell proliferation and viability levels to wild-type Map2k1 in culture (PMID: 29533785), and therefore, its effect on Map2k1 protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 P124S

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Transcript NM_002755.4
gDNA chr15:g.66436824C>T
cDNA c.370C>T
Protein p.P124S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.3 chr15:g.66436824C>T c.370C>T p.P124S RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66436824C>T c.370C>T p.P124S RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66436824C>T c.370C>T p.P124S RefSeq GRCh38/hg38
XM_017022411 chr15:g.66436824C>T c.370C>T p.P124S RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66436824C>T c.370C>T p.P124S RefSeq GRCh38/hg38
NM_002755 chr15:g.66436824C>T c.370C>T p.P124S RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries