RET Y791F
Gene Variant Detail

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Gene RET
Variant Y791F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET Y791F lies within the protein kinase domain of the Ret protein (UniProt.org). Y791F results in ligand-independent kinase activity and activation of Stat3 signaling and is transforming in cell culture (PMID: 17209045, PMID: 15753368), but does not respond to growth factor stimulation in culture (PMID: 17209045) and results in enteric nervous system development similar to wild-type in a transgenic mouse model (PMID: 32275061), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET Y791X RET Y791F

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Transcript NM_020975.6
gDNA chr10:g.43118460A>T
cDNA c.2372A>T
Protein p.Y791F
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.