Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RET
Variant Y791F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET Y791F lies within the protein kinase domain of the Ret protein (UniProt.org). Y791F results in ligand-independent kinase activity and activation of Stat3 signaling and is transforming in cell culture (PMID: 17209045, PMID: 15753368), but does not respond to growth factor stimulation in culture (PMID: 17209045) and results in enteric nervous system development similar to wild-type in a transgenic mouse model (PMID: 32275061), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET Y791X RET Y791F

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_020975.6
gDNA chr10:g.43118460A>T
cDNA c.2372A>T
Protein p.Y791F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43128193A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020975 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43128193A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET Y791F Advanced Solid Tumor sensitive Ponatinib Preclinical - Biochemical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET Y791F in culture (PMID: 23526464). 23526464
RET Y791F Advanced Solid Tumor sensitive Vandetanib Preclinical Actionable In a preclinical study, Caprelsa (vandetanib) inhibited Ret autophosphorylation in transformed cells expressing RET Y791F in culture (PMID: 15184865). 15184865