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Gene RET
Variant Y791F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET Y791F lies within the protein kinase domain of the Ret protein (UniProt.org). Y791F results in ligand-independent kinase activity and activation of Stat3 signaling and is transforming in cell culture (PMID: 17209045, PMID: 15753368), but does not respond to growth factor stimulation in culture (PMID: 17209045) and results in enteric nervous system development similar to wild-type in a transgenic mouse model (PMID: 32275061), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET Y791X RET Y791F

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Transcript NM_020975.6
gDNA chr10:g.43118460A>T
cDNA c.2372A>T
Protein p.Y791F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43128193A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020630 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43128193A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020975 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118460A>T c.2372A>T p.Y791F RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET Y791F Advanced Solid Tumor sensitive Ponatinib Preclinical - Biochemical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET Y791F in culture (PMID: 23526464). 23526464
RET Y791F Advanced Solid Tumor sensitive Vandetanib Preclinical Actionable In a preclinical study, Caprelsa (vandetanib) inhibited Ret autophosphorylation in transformed cells expressing RET Y791F in culture (PMID: 15184865). 15184865