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FGFR2 E566A - Gene Variant Detail

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Gene FGFR2
Variant E566A
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 E566A (corresponds to E565A in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E566A results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937, PMID: 28166054) and is also associated with resistance to FGFR inhibitors (PMID: 31109923).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 E566A

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Transcript NM_022970.4
gDNA chr10:g.121496701T>G
cDNA c.1697A>C
Protein p.E566A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121496701T>G c.1697A>C p.E566A RefSeq GRCh38/hg38
XM_024447887.1 chr10:g.121488070T>G c.1697A>C p.E566A RefSeq GRCh38/hg38
NM_022970 chr10:g.121496701T>G c.1697A>C p.E566A RefSeq GRCh38/hg38
XM_024447887.2 chr10:g.121488070T>G c.1697A>C p.E566A RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496701T>G c.1697A>C p.E566A RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496701T>G c.1697A>C p.E566A RefSeq GRCh38/hg38
NM_001144913 chr10:g.121496701T>G c.1697A>C p.E566A RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121496701T>G c.1697A>C p.E566A RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 E566A Advanced Solid Tumor predicted - sensitive TYRA-200 Preclinical - Biochemical Actionable In a preclinical study, TYRA-200 inhibited FGFR2 E566A in an in vitro assay (Eur J Cancer 2022 Vol 174, Supp 1:S16). detail...