TP53 Y220C
Gene Variant Detail

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Gene TP53
Variant Y220C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 Y220C is a hotspot mutation that lies within the DNA-binding domain (PMID: 17401432). Y220C results in decreased DNA binding, reduced Tp53 transcriptional activity, leads to resistance to apoptosis and failure of G1 arrest in cell culture (PMID: 16861262, PMID: 23630318, PMID: 31395785).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 Y220C

TP53 mutant TP53 inact mut TP53 Y220C

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Transcript NM_000546.6
gDNA chr17:g.7674872T>C
cDNA c.659A>G
Protein p.Y220C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07060989 Phase Ib/II NTS071 A Study of Safety, Tolerability and Preliminary Efficacy of NTS071 in Subjects With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (NTS071) Not yet recruiting USA 1
NCT04585750 Phase Ib/II PC14586 + Pembrolizumab PC14586 The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE) Recruiting USA | ITA | GBR | FRA | ESP | DEU | AUS 2
NCT06616636 Phase I Azacitidine + PC14586 Azacitidine + PC14586 + Venetoclax A Phase Ib Study of Rezatapopt in Combination with Azacitidine or Azacitidine and Venetoclax in Patients with TP53Y220C Mutant Myeloid Malignancies (Acute Myeloid Leukemia or Myelodysplastic Syndrome) Recruiting USA 0
NCT06386146 Phase Ib/II JAB-30355 JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation Recruiting USA 1