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Therapy Name JAB-30355
Synonyms
Therapy Description

JAB-30355 is a selective TP53 Y220C reactivator, which increases expression of TP53 target genes and potentially decreases tumor cell viability and inhibits growth of tumors harboring TP53 Y220C (Cancer Res (2024) 84 (6_Supplement): 5940).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
JAB-30355 JAB 30355|JAB30355 JAB-30355 is a selective TP53 Y220C reactivator, which increases expression of TP53 target genes and potentially decreases tumor cell viability and inhibits growth of tumors harboring TP53 Y220C (Cancer Res (2024) 84 (6_Supplement): 5940).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06386146 Phase Ib/II JAB-30355 JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation Recruiting USA 1


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