TP53 Y220C
Gene Variant Detail

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Gene TP53
Variant Y220C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 Y220C is a hotspot mutation that lies within the DNA-binding domain (PMID: 17401432). Y220C results in decreased DNA binding, reduced Tp53 transcriptional activity, leads to resistance to apoptosis and failure of G1 arrest in cell culture (PMID: 16861262, PMID: 23630318, PMID: 31395785).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 Y220C

TP53 mutant TP53 inact mut TP53 Y220C

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Transcript NM_000546.6
gDNA chr17:g.7674872T>C
cDNA c.659A>G
Protein p.Y220C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.3 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_000546 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674872T>C c.659A>G p.Y220C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 Y220C loss of function p53 Activator p53 Gene Therapy
TP53 P72R TP53 Y220C
TP53 F109S TP53 Y220C
TP53 L145P TP53 Y220C
TP53 V147L TP53 Y220C
TP53 P151R TP53 Y220C
TP53 P152R TP53 Y220C
TP53 R175H TP53 Y220C
TP53 Y220C TP53 R248W
TP53 Y220C TP53 R273C
TP53 Y220C TP53 R282W
TP53 Y220C TP53 L265_G266del
TP53 Y220C TP53 N288fs
TP53 P151A TP53 Y220C
TP53 P152L TP53 Y220C