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| Profile Name | TP53 V147L TP53 Y220C |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| TP53 V147L TP53 Y220C | Advanced Solid Tumor | resistant | Rezatapopt | Preclinical - Cell culture | Actionable | In a preclinical study, cancer cell lines expressing TP53 Y220C and V147L were resistant to Rezatapopt (PC14586) treatment in culture (PMID: 41504628). | 41504628 |