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Profile Name KEAP1 mutant
Gene Variant Detail

KEAP1 mutant (unknown)

Relevant Treatment Approaches

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04250545 Phase I Sapanisertib + Telaglenastat Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer Active, not recruiting USA 0
NCT04265534 Phase II Carboplatin + Dexamethasone + Pembrolizumab + Pemetrexed Disodium + Telaglenastat Carboplatin + Dexamethasone + Pembrolizumab + Pemetrexed Disodium KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC (KEAPSAKE) Terminated USA 0
NCT06431633 Phase II Zimberelimab Cisplatin Sacituzumab govitecan-hziy + Zimberelimab Carboplatin Study of Treatment with Sacituzumab and Zimberelimab for Patients with Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free. (ARIAN) Recruiting ESP 0
NCT06130254 Phase I Adagrasib + Olaparib Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers Recruiting USA 0
NCT04471415 Phase Ib/II DRP-104 Atezolizumab + DRP-104 Study to Investigate DRP-104 in Adults With Advanced Solid Tumors Terminated USA | ESP | DEU 2
NCT04564157 Phase III Carboplatin + Nivolumab + Paclitaxel Carboplatin + Paclitaxel New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy (NADIM-ADJUVANT) Active, not recruiting ESP 0
NCT06008093 Phase III Cisplatin + Pembrolizumab + Pemetrexed Disodium Cisplatin + Durvalumab + Pemetrexed Disodium + Tremelimumab Carboplatin + Pembrolizumab + Pemetrexed Disodium Carboplatin + Durvalumab + Pemetrexed Disodium + Tremelimumab A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients (TRITON) Recruiting USA 0
NCT04916236 Phase I LY3214996 + RMC-4630 Combination Therapy of RMC-4630 and LY3214996 in Metastatic KRAS Mutant Cancers (SHERPA) Terminated NLD 0
NCT05275868 Phase I MGY825 Study of MGY825 in Patients With Advanced Non-small Cell Lung Cancer Terminated USA | ESP | DEU | CHE 2
NCT07249372 Phase II DRP-104 DRP-104 in Patients With NFE2L2/KEAP1-altered Non-Small Cell Lung Cancer Recruiting USA 0
NCT02417701 Phase II Sapanisertib Sapanisertib in Treating Patients With Stage IV or Recurrent Lung Cancer Completed USA 0
NCT03872427 Phase II Telaglenastat Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study Active, not recruiting USA 0