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| Profile Name | ALK fusion ALK C1156Y |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ALK fusion ALK C1156Y | lung adenocarcinoma | predicted - sensitive | Alectinib | Case Reports/Case Series | Actionable | In a retrospective analysis, Alecensa (alectinib) treatment resulted in a partial response with a progression-free survival of 6.3 months, overall survival of 8.2 months, and a duration of treatment of 8.1 months in a patient with lung adenocarcinoma harboring an ALK fusion with ALK C1156Y (PMID: 39500140). | 39500140 |