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| Profile Name | MST1R act mut |
| Gene Variant Detail | |
| Relevant Treatment Approaches | RON Inhibitor Narnatumab Zt/f2 Zt/g4 Zt/g4-DM1 |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| MST1R act mut | breast cancer | predicted - sensitive | RON Inhibitor | BMS-777607 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, BMS-777607 (ASLAN002) inhibited tumor growth in breast cancer cell line xenograft models expressing a constitutively active short isoform of MST1R (RON) (PMID: 26289070). | 26289070 |
| MST1R act mut | breast cancer | predicted - sensitive | RON Inhibitor | OSI-296 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, OSI-296 inhibited tumor growth in breast cancer cell line xenograft models expressing a constitutively active short isoform of MST1R (RON) (PMID: 26289070). | 26289070 |
| MST1R act mut | breast cancer | predicted - sensitive | RON Inhibitor | BMS-777607 + Buparlisib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of BKM120 and BMS-777607 (ASLAN002) inhibited tumor growth in breast cancer cell line xenograft models expressing a constitutively active short isoform of MST1R (RON), with increased efficacy over either agent alone (PMID: 26289070). | 26289070 |