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| Profile Name | RB1 dec exp |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| RB1 dec exp | Advanced Solid Tumor | no benefit | Dalpiciclib | Preclinical - Cell culture | Actionable | In a preclinical study, Dalpiciclib (SHR6390) demonstrated limited cytotoxic activity against tumor cell lines with low Rb1 expression in culture (PMID: 30724426). | 30724426 |