Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Relevant Treatment Approaches	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT V559_V560del	Advanced Solid Tumor	sensitive	KIT Inhibitor	Sunitinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT V559_V560del were sensitive to Sutent (sunitinib), demonstrating decreased cell proliferation in culture (PMID: 24205792).	24205792
KIT V559_V560del	Advanced Solid Tumor	sensitive	KIT Inhibitor	Imatinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT V559_V560del were sensitive to Gleevec (imatinib), demonstrating decreased cell proliferation in culture (PMID: 24205792).	24205792
KIT V559_V560del	Advanced Solid Tumor	sensitive	KIT Inhibitor	Flumatinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT V559_V560del were sensitive to Flumatinib, demonstrating decreased cell proliferation in culture (PMID: 24205792).	24205792

Profile Name	KIT V559_V560del
Gene Variant Detail	KIT V559_V560del (gain of function)
Relevant Treatment Approaches	KIT Inhibitor