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| Profile Name | NTRK1 over exp |
| Gene Variant Detail | |
| Relevant Treatment Approaches | Trk Receptor Inhibitor (Pan) TrkA Receptor Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| NTRK1 over exp | neuroblastoma | sensitive | TrkA Receptor Inhibitor | GW441756 | Preclinical | Actionable | In a preclinical study, GW441756, a TrkA inhibitor, blocked tyrosine phosphorylation of ERK and JNK induced by TrkA over expression in neuroblastoma cells (PMID: 23319303). | 23319303 |
| NTRK1 over exp | neuroblastoma | sensitive | Trk Receptor Inhibitor (Pan) | GTx-186 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GTx-186 inhibited Erk signaling, resulted in growth inhibition of neuroblastoma cells overexpressing Ntrk1 in culture and in cell line xenograft models (PMID: 24386191). | 24386191 |