Molecular Profile Detail

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Profile Name NTRK1 over exp
Gene Variant Detail

NTRK1 over exp (no effect)

Relevant Treatment Approaches Trk Receptor Inhibitor (Pan) TrkA Receptor Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 over exp neuroblastoma sensitive TrkA Receptor Inhibitor GW441756 Preclinical Actionable In a preclinical study, GW441756, a TrkA inhibitor, blocked tyrosine phosphorylation of ERK and JNK induced by TrkA over expression in neuroblastoma cells (PMID: 23319303). 23319303
NTRK1 over exp neuroblastoma sensitive Trk Receptor Inhibitor (Pan) GTx-186 Preclinical - Cell line xenograft Actionable In a preclinical study, GTx-186 inhibited Erk signaling, resulted in growth inhibition of neuroblastoma cells overexpressing Ntrk1 in culture and in cell line xenograft models (PMID: 24386191). 24386191