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| Profile Name | JAK2 Y931C |
| Gene Variant Detail | |
| Relevant Treatment Approaches | JAK Inhibitor (Pan) JAK2 Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| JAK2 Y931C | cancer | resistant | Ruxolitinib | Preclinical | Actionable | In a preclinical study, cells harboring JAK2 Y931C displayed resistance to ATP-competetive JAK inhibitors, such as Jakafi (Ruxolitinib) (PMID: 21393331). | 21393331 |