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Profile Name | JAK1 V658F JAK1 F958C |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK1 V658F JAK1 F958C | cancer | resistant | Ruxolitinib | Preclinical | Actionable | In a preclinical study, cells harboring the JAK1 V658F/F958C double mutation displayed resistance to ATP-competetive JAK inhibitors, such as Jakafi (Ruxolitinib) (PMID: 21393331). | 21393331 |