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Profile Name | RB1 negative |
Gene Variant Detail | |
Relevant Treatment Approaches | HDAC Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
RB1 negative | breast cancer | no benefit | Dalpiciclib | Preclinical - Cell culture | Actionable | In a preclinical study, Dalpiciclib (SHR6390) demonstrated little cytotoxic activity against a RB1-negative breast cancer cell line in culture (PMID: 30724426). | 30724426 |