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| Profile Name | PDGFRB positive |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| PDGFRB positive | mixed epithelial stromal tumour | sensitive | Imatinib | Preclinical - Cell culture | Actionable | In a preclinical study, epithelial stromal tumor cells of the seminal vescicle from a prostate adenocarcinoma mouse model expressing PDGFRB demonstrated sensitivity to Gleevec (imatinib) in culture, resulting in inhibition of cell proliferation (PMID: 27980106). | 27980106 |