Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Relevant Treatment Approaches	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT T417_D419delinsI	Advanced Solid Tumor	conflicting	KIT Inhibitor	Imatinib	Preclinical - Cell culture	Actionable	In a preclinical study, Gleevec (imatinib mesylate) inhibited Kit phosphorylation in transformed cells over expressing KIT T417_D419delinsI in culture (PMID: 16015387).	16015387
KIT T417_D419delinsI	Advanced Solid Tumor	conflicting	KIT Inhibitor	Imatinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T417_D419delinsI were resistant to treatment with Gleevec (imatinib) in culture (PMID: 24205792).	24205792
KIT T417_D419delinsI	Advanced Solid Tumor	sensitive	KIT Inhibitor	Flumatinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T417_D419delinsI were sensitive to treatment with Flumatinib, demonstrating decreased cell proliferation (PMID: 24205792).	24205792
KIT T417_D419delinsI	Advanced Solid Tumor	sensitive	KIT Inhibitor	Sunitinib	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT T417_D419delinsI were sensitive to treatment with Sutent (sunitinib), demonstrating decreased cell proliferation (PMID: 24205792).	24205792

Profile Name	KIT T417_D419delinsI
Gene Variant Detail	KIT T417_D419delinsI (gain of function - predicted)
Relevant Treatment Approaches	KIT Inhibitor