Molecular Profile Detail

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Profile Name BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
Gene Variant Detail

BRAF V600X (unknown)

MAP2K1 V60E (gain of function)

NRAS Q61R (loss of function - predicted)

NRAS T58I (loss of function - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R melanoma predicted - resistant Vemurafenib Clinical Study - Cohort Actionable In a clinical study, a melanoma patient harboring a BRAF V600 mutation developed resistance-associated mutations, MAP2K1 V60E, NRAS T58I, and NRAS Q61R, after 18 weeks of treatment with Zelboraf (vemurafenib) (PMID: 24265153). 24265153