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| Profile Name | IDH1 R132C SRC T341I |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| IDH1 R132C SRC T341I | intrahepatic cholangiocarcinoma | resistant | Dasatinib | Preclinical - Cell culture | Actionable | In a preclinical study, acquisition of SRC T341I in intrahepatic cholangiocarcinoma cells harboring IDH1 R132C was associated with resistance to Sprycel (dasatinib) in culture (PMID: 27231123). | 27231123 |