Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF mut RB1 loss	melanoma	decreased response	Palbociclib	Preclinical - Cell culture	Actionable	In a preclinical study, a melanoma cell line harboring a BRAF mutation and loss of RB1 demonstrated a decreased response to Ibrance (palbociclib) treatment in culture when compared to treatment of melanoma cell lines wild-type for BRAF (PMID: 27488531).	27488531
BRAF mut RB1 loss	melanoma	decreased response	Trametinib	Preclinical - Cell culture	Actionable	In a preclinical study, a melanoma cell line harboring a BRAF mutation and RB1 loss demonstrated reduced sensitivity when treated with Mekinist (trametinib) in culture (PMID: 27488531).	27488531
BRAF mut RB1 loss	melanoma	decreased response	Palbociclib + Trametinib	Preclinical - Cell culture	Actionable	In a preclinical study, a melanoma cell line with a BRAF mutation and loss of RB1 demonstrated minimal sensitivity when treated with the combination of Ibrance (palbociclib) and Mekinist (trametinib) in culture (PMID: 27488531).	27488531

Profile Name	BRAF mut RB1 loss
Gene Variant Detail	BRAF mutant (unknown) RB1 loss (loss of function)
Relevant Treatment Approaches