Molecular Profile Detail

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Profile Name BTK mutant
Gene Variant Detail

BTK mutant (unknown)

Relevant Treatment Approaches

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02914327 Phase I Ibrutinib + SNX-5422 Safety and Activity of SNX-5422 Plus Ibrutinib in CLL Withdrawn USA 0
NCT04189757 Phase II Acalabrutinib Acalabrutinib for the Treatment of Ibrutinib-Intolerant Mantle Cell Lymphoma Active, not recruiting USA 0
NCT04883749 Phase II Acalabrutinib Efficacy of Acalabrutinib in Very Old or Frail Patients with Treatment-naïve or Relapsed/Refractory CLL (CLL-Frail) Completed DEU | AUT 0
NCT03331198 Phase Ib/II Lisocabtagene maraleucel Ibrutinib + Lisocabtagene maraleucel Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Active, not recruiting USA | CAN 0
NCT04209621 Phase II Duvelisib + Ibrutinib Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Terminated USA 0
NCT04515238 Phase II Bendamustine + Obinutuzumab + Venetoclax + Zanubrutinib Sequential Regimen of Bendamustine Followed by Obinutuzumab (GA101), Zanubrutinib (BGB-3111) and Venetoclax (ABT-199) in Patients With Relapsed/Refractory CLL (CLL2-BZAG) Active, not recruiting DEU 0