Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Profile Name | MSH2 loss |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
MSH2 loss | colorectal cancer | sensitive | Cytarabine | Preclinical | Actionable | In a preclinical study, colorectal cancer cells deficient in MSH2 had increased sensitivity to Cytosar-U (cytarabine) in culture (PMID: 23361057). | 23361057 | |
MSH2 loss | endometrial carcinoma | not applicable | N/A | Preclinical | Emerging | Preclinical shRNA mediated-inhibition of POLB in human endometrial carcinoma cells with MSH2 loss resulted in synthetic lethality, suggesting POLB may be a promising therapeutic target for MSH2 deficient cancer cells (PMID: 20227038). | 20227038 |