Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Relevant Treatment Approaches	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PDGFRB P584R	Advanced Solid Tumor	sensitive	PDGFR Inhibitor (Pan)	Imatinib	Preclinical - Cell culture	Actionable	In a preclinical study, Gleevec (imatinib) inhibited PDGFRB downstream signaling and proliferation of transformed cells expressing PDGFRB P584R in culture (PMID: 26455322).	26455322
PDGFRB P584R	Advanced Solid Tumor	sensitive	PDGFR Inhibitor (Pan)	Nilotinib	Preclinical - Cell culture	Actionable	In a preclinical study, Tasigna (nilotinib) inhibited PDGFRB downstream signaling and proliferation of transformed cells expressing PDGFRB P584R in culture (PMID: 26455322).	26455322
PDGFRB P584R	Advanced Solid Tumor	sensitive		Ponatinib	Preclinical - Cell culture	Actionable	In a preclinical study, Iclusig (ponatinib) inhibited PDGFRB downstream signaling and proliferation of transformed cells expressing PDGFRB P584R in culture (PMID: 26455322).	26455322

Profile Name	PDGFRB P584R
Gene Variant Detail	PDGFRB P584R (gain of function)
Relevant Treatment Approaches	PDGFR Inhibitor (Pan) PDGFR-beta Inhibitor