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| Profile Name | MST1R pos PIK3CA wild-type |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| MST1R pos PIK3CA wild-type | estrogen-receptor positive breast cancer | predicted - sensitive | BMS-777607 + Buparlisib | Preclinical - Pdx | Actionable | In a preclinical study, the combination of BKM120 and BMS-777607 (ASLAN002) inhibited tumor growth in patient-derived xenograft (PDX) models of estrogen-receptor positive breast cancer with wild-type PIK3CA and expressing the short isoform of MST1R (RON) (PMID: 26289070). | 26289070 | |
| MST1R pos PIK3CA wild-type | estrogen-receptor positive breast cancer | predicted - sensitive | Buparlisib | Preclinical - Pdx | Actionable | In a preclinical study, BKM120 inhibited tumor growth in patient-derived xenograft (PDX) models of estrogen-receptor positive breast cancer with wild-type PIK3CA and expressing the short isoform of MST1R (RON) (PMID: 26289070). | 26289070 | |
| MST1R pos PIK3CA wild-type | estrogen-receptor positive breast cancer | predicted - sensitive | BMS-777607 | Preclinical - Pdx | Actionable | In a preclinical study, BMS-777607 (ASLAN002) inhibited tumor growth in patient-derived xenograft (PDX) models of estrogen-receptor positive breast cancer with wild-type PIK3CA and expressing the short isoform of MST1R (RON) (PMID: 26289070). | 26289070 |