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Profile Name | APC I1164fs |
Gene Variant Detail | |
Relevant Treatment Approaches | CTNNB1 Inhibitor Tankyrase Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
APC I1164fs | colorectal cancer | sensitive | Tankyrase Inhibitor | G007-LK | Preclinical - Patient cell culture | Actionable | In a preclinical study, G007-LK inhibited growth of a patient-derived colorectal cancer cell line harboring APC I1164fs in culture (PMID: 28179481). | 28179481 |
APC I1164fs | colorectal cancer | sensitive | Tankyrase Inhibitor | IWR-1 | Preclinical - Cell culture | Actionable | In a preclinical study, IWR-1 inhibited growth of a patient-derived colorectal cancer cell line harboring APC I1164fs in culture (PMID: 28179481). | 28179481 |