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| Profile Name | PDGFRB N666H |
| Gene Variant Detail | |
| Relevant Treatment Approaches | PDGFR Inhibitor (Pan) PDGFR-beta Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| PDGFRB N666H | Advanced Solid Tumor | sensitive | PDGFR Inhibitor (Pan) | Imatinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Gleevec (imatinib mesylate) inhibited Pdgfrb phosphorylation, resulting in growth inhibition of transformed cells overexpressing PDGFRB N666H and in primary cells derived from a patient harboring germline PDGFRB N666H (PMID: 28726812). | 28726812 |