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Profile Name | RET positive |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
RET positive | breast cancer | sensitive | Y078-DM4 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Y078-DM4 induced cytotoxicity in RET-expressing human breast cancer cell lines in culture and inhibited tumor growth in xenograft models (PMID: 26240273). | 26240273 | |
RET positive | medullary thyroid carcinoma | sensitive | Y078-DM4 | Preclinical | Actionable | In a preclinical study, Y078-DM4 induced cytotoxicity in a RET-expressing medullary thyroid cell line in culture (PMID: 26240273). | 26240273 |