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| Profile Name | FGFR3 V50I |
| Gene Variant Detail | |
| Relevant Treatment Approaches | FGFR Inhibitor (Pan) FGFR3 Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| FGFR3 V50I | Advanced Solid Tumor | resistant | FGFR Inhibitor (Pan) | Erdafitinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing FGFR3 V50I were resistant to Balversa (erdafitinib) in culture (PMID: 40526877). | 40526877 |
| FGFR3 V50I | Advanced Solid Tumor | resistant | FGFR3 Inhibitor | Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing FGFR3 V50I were resistant to Fexagratinib (AZD4547) in culture (PMID: 40526877). | 40526877 |