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| Profile Name | APC R1450* |
| Gene Variant Detail | |
| Relevant Treatment Approaches | CTNNB1 Inhibitor Tankyrase Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| APC R1450* | colorectal cancer | sensitive | Tankyrase Inhibitor | STP1002 | Preclinical - Pdx | Actionable | In a preclinical study, STP1002 inhibited tumor growth in a colorectal cancer patient-derived xenograft (PDX) model harboring APC R1450* (PMID: 35849876). | 35849876 |