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Profile Name | RET G810S |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
RET G810S | Advanced Solid Tumor | predicted - sensitive | TPX-0046 | Preclinical - Cell culture | Actionable | In a preclinical study, TPX-0046 treatment led to inhibition of cell proliferation in a transformed cell line expressing RET G810S in culture (J Clin Oncol 38, no. 15_suppl (May 20, 2020) 3616-3616). | detail... | |
RET G810S | Advanced Solid Tumor | predicted - sensitive | APS03118 | Preclinical - Cell culture | Actionable | In a preclinical study, APS03118 inhibited the enzymatic activity of RET G810S in an in vitro assay and inhibited proliferation of cells expressing RET G810S in culture (J Clin Oncol 40, no. 16_suppl (June 1, 2022)). | detail... | |
RET G810S | Advanced Solid Tumor | predicted - sensitive | TY-1091 | Preclinical - Cell culture | Actionable | In a preclinical study, TY-1091 inhibited activity in a cell line expressing RET G810S in culture (Cancer Res (2023) 83 (7_Supplement): 3419). | detail... |