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| Profile Name | CD274 rearrange |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| CD274 rearrange | ovarian carcinoma | sensitive | Pembrolizumab | Case Reports/Case Series | Actionable | In a clinical case study, a patient with high grade ovarian carcinoma harboring a CD274 rearrangement demonstrated a complete response when treated with Keytruda (pembrolizumab) (PMID: 29351920). | 29351920 |