Molecular Profile Detail

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Profile Name APC dec exp
Gene Variant Detail

APC dec exp (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC dec exp colorectal cancer predicted - sensitive G007-LK Preclinical Actionable In a preclinical study, G007-LK treatment altered gene expression pattern and induced growth arrest in intestinal organoids established from mouse models of colorectal cancer driven by APC knockdown, decreased proliferation and promoted differentiation in APC knockdown mouse models (PMID: 31337618). 31337618