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Profile Name | B2M L13fs B2M LOH |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
B2M L13fs B2M LOH | melanoma | predicted - resistant | Ipilimumab | Case Reports/Case Series | Actionable | In a clinical case study, B2M loss of heterozygosity (LOH) and L13fs were identified as acquired mutations in one lineage of resistant tumor cells in a melanoma patient whose disease progressed on Yervoy (ipilimumab) treatment, B2M LOH and L13fs were also identified in the pre-treatment biopsy of a melanoma patient who did not respond to Yervoy (ipilimumab) treatment (PMID: 29070816). | 29070816 | |
B2M L13fs B2M LOH | melanoma | predicted - resistant | Pembrolizumab | Case Reports/Case Series | Actionable | In a clinical case study, a melanoma patient with acquired B2M loss of heterozygosity (LOH) and L13fs did not respond to Keytruda (pembrolizumab) treatment (PMID: 29070816). | 29070816 |