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Profile Name | JAK2 V617F JAK2 Y931C JAK2 V1075F |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK2 V617F JAK2 Y931C JAK2 V1075F | Advanced Solid Tumor | resistant | Fedratinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing JAK2 V617F, Y931C and V1075F demonstrated resistance to Inrebic (fedratinib) treatment in culture (PMID: 26419724). | 26419724 |