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| Profile Name | AXL pos FLT3 exon 14 ins |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| AXL pos FLT3 exon 14 ins | acute myeloid leukemia | sensitive | ONO-7475 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ONO-7475 treatment inhibited phosphorylation of Flt3, Erk and S6, induced apoptosis and cell cycle arrest, and reduced viability of acute myeloid leukemia cell lines expressing AXL and harboring FLT3-ITD in culture, and increased median survival in a cell line xenograft model (PMID: 28912176). | 28912176 | |
| AXL pos FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Cytarabine + ONO-7475 | Preclinical - Cell culture | Actionable | In a preclinical study, ONO-7475 combined with Cytosar-U (cytarabine) treatment resulted in enhanced reduction in viability and induction of apoptosis in acute myeloid leukemia cell lines expressing AXL and harboring FLT3-ITD in culture (PMID: 28912176). | 28912176 |