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Profile Name | FLT3 E598_Y599insFDFREYE FLT3 R845G |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
FLT3 E598_Y599insFDFREYE FLT3 R845G | B-cell adult acute lymphocytic leukemia | sensitive | Quizartinib | Preclinical - Cell culture | Actionable | In a preclinical study, B-cell acute lymphocytic leukemia cells harboring FLT3 R845G and FLT3 E598_Y599insFDFREYE were sensitive to treatment with Vanflyta (quizartinib), demonstrating decreased cell viability in culture (PMID: 30962949). | 30962949 | |
FLT3 E598_Y599insFDFREYE FLT3 R845G | B-cell adult acute lymphocytic leukemia | sensitive | Crenolanib | Preclinical - Cell culture | Actionable | In a preclinical study, B-cell acute lymphocytic leukemia cells harboring FLT3 R845G and FLT3 E598_Y599insFDFREYE were sensitive to treatment with Crenolanib, demonstrating decreased cell viability in culture (PMID: 30962949). | 30962949 |