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| Profile Name | KDR wild-type |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| KDR wild-type | Advanced Solid Tumor | predicted - sensitive | Ramucirumab | Phase I | Actionable | In a Phase I trial, Cyramza (ramucirumab), an inhibitor of KDR (VEGFR2), demonstrated safety and efficacy (partial response or stable disease) in patients with advanced solid tumors (PMID: 20048182). | 20048182 | |
| KDR wild-type | pancreatic cancer | sensitive | Elpamotide + Gemcitabine | Phase I | Actionable | In a Phase I trial, Elpamotide (VEGFR2-169), in combination with Gemzar (gemcitabine), achieved a disease control rate of 67% (12/18) and an improved overall survival time to 8.7 months in pancreatic cancer patients expressing the HLA-A*2402 version of the KDR (VEGFR2) wild-type allele (PMID: 19930156). | 19930156 |