Molecular Profile Detail

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Profile Name KIT V559X KIT N822I
Gene Variant Detail

KIT N822I (gain of function)

KIT V559X (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT V559X KIT N822I melanoma predicted - sensitive Imatinib + Pembrolizumab Case Reports/Case Series Actionable In a clinical case study, addition of Gleevec (imatinib) to Keytruda (pembrolizumab) in a patient with metastatic melanoma harboring an unspecified KIT V559 mutation and a KIT N822I resulted in a complete remission after 6 months and the patient stayed on therapy for 2 years (PMID: 31689840). 31689840