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| Profile Name | FLT3 exon 14 ins FLT3 E654D |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 E654D | acute myeloid leukemia | predicted - sensitive | Olverembatinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Olverembatinib (HQP1351) reduced Flt3 and Stat5 activation and inhibited growth of patient-derived acute myeloid leukemia cells harboring FLT3-ITD and FLT3 E654D in culture (PMID: 32247263). | 32247263 |