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Molecular Profile Detail

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Profile Name MAP2K1 P105_A106del
Gene Variant Detail

MAP2K1 P105_A106del (gain of function)

Relevant Treatment Approaches MEK inhibitor (Pan) MEK1 Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 P105_A106del Advanced Solid Tumor resistant MEK inhibitor (Pan) MEK1 Inhibitor Trametinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing MAP2K1 P105_A106del were resistant to Mekinist (trametinib) in culture (PMID: 36442478). 36442478
MAP2K1 P105_A106del Advanced Solid Tumor predicted - sensitive SCH772984 Preclinical - Biochemical Actionable In a preclinical study, SCH772984 inhibited downstream signaling in transformed cells expressing MAP2K1 P105_A106del in culture (PMID: 32641410). 32641410
MAP2K1 P105_A106del Advanced Solid Tumor resistant MEK inhibitor (Pan) MEK1 Inhibitor Trametinib Preclinical - Biochemical Actionable In a preclinical study, transformed cells expressing MAP2K1 P105_A106del were less sensitive to Mekinist (trametinib) compared to similar mutations in the negative regulatory domain of the Map2k1 protein in culture (PMID: 32641410). 32641410