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Profile Name | TP53 Q331* |
Gene Variant Detail | |
Relevant Treatment Approaches | p53 Gene Therapy |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
TP53 Q331* | lung non-small cell carcinoma | sensitive | AZ32 + Radiotherapy | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AZ32 treatment increased sensitivity to radiotherapy and demonstrated increased tumor growth inhibition and prolonged survival compared to radiation alone in an intracranial cell line xenograft model of non-small cell lung cancer brain metastasis harboring TP53 Q331* (PMID: 29769307). | 29769307 |