Molecular Profile Detail

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Profile Name PDGFRB act mut
Gene Variant Detail

PDGFRB act mut (gain of function)

Relevant Treatment Approaches PDGFR Inhibitor (Pan) PDGFR-beta Inhibitor

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05208047 Phase III Sunitinib PLX9486 + Sunitinib Midazolam + PLX9486 + Sunitinib (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors Recruiting USA | SWE | POL | NOR | NLD | ITA | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | AUS | ARG 5
NCT04501614 Phase Ib/II Ponatinib A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Terminated USA | POL | NLD | ITA | GBR | FRA | ESP | CZE | BRA | AUS | ARG 4
NCT06948955 Expanded access PLX9486 + Sunitinib Expanded Access to Bezuclastinib to be Coadministered With Sunitinib for Patients With Gastrointestinal Stromal Tumors Available USA 0