Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Relevant Treatment Approaches	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FGFR2 H167_N173del FGFR2 L618F	intrahepatic cholangiocarcinoma	predicted - resistant		Zoligratinib	Case Reports/Case Series	Actionable	In a Phase I trial, an intrahepatic cholangioncarcinoma patient who progressed in Debio 1347 was found to have acquired FGFR2 L618F, and co-expression of FGFR2 H167_N173del and FGFR2 L618F an intrahepatic cholangiocarcinoma cell line led to a reduced response to Debio 1347 treatment compared to cells expressing wild-type FGFR2 in culture (PMID: 33926920).	33926920
FGFR2 H167_N173del FGFR2 L618F	intrahepatic cholangiocarcinoma	predicted - sensitive		Futibatinib	Case Reports/Case Series	Actionable	In a Phase I trial, Lytgobi (futibatinib) treatment led to a partial response with 61% tumor reduction and response duration of 17 months in an intrahepatic cholangiocarcinoma patient harboring FGFR2 H167_N173del and FGFR2 L618F, which was consistent with inhibition of growth in an intrahepatic cholangiocarcinoma cell line expressing FGFR2 H167_N173del and FGFR2 L618F in culture (PMID: 33926920).	33926920

Profile Name	FGFR2 H167_N173del FGFR2 L618F
Gene Variant Detail	FGFR2 H167_N173del (gain of function) FGFR2 L618F (unknown)
Relevant Treatment Approaches