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Profile Name | JAK2 LOH JAK2 inact mut |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK2 LOH JAK2 inact mut | melanoma | predicted - sensitive | VSV-delta51 | Preclinical - Patient cell culture | Actionable | In a preclinical study, a melanoma patient-derived cell line harboring an inactivating JAK2 mutation and JAK2 loss of heterozygosity resulted in sensitivity to treatment with an oncolytic virus, VSV-delta51, in culture (PMID: 33593882). | 33593882 | |
JAK2 LOH JAK2 inact mut | melanoma | predicted - sensitive | HSV1-dICP0 | Preclinical - Patient cell culture | Actionable | In a preclinical study, a melanoma patient-derived cell line harboring an inactivating JAK2 mutation and JAK2 loss of heterozygosity resulted in sensitivity to treatment with an oncolytic virus, HSV1-dICP0, in culture (PMID: 33593882). | 33593882 |