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Molecular Profile Detail

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Profile Name MAP2K1 E203K PIK3CA amp
Gene Variant Detail

MAP2K1 E203K (gain of function)

PIK3CA amp (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 E203K PIK3CA amp skin squamous cell carcinoma predicted - sensitive Metformin + Trametinib Case Reports/Case Series Actionable In a clinical case study, a combination of Glucophage (metformin) and Mekinist (trametinib) resulted in a complete clinical response and continued remission for over two years in a patient with cutaneous squamous cell carcinoma with amplification of PIK3CA and harboring MAP2K1 E203K (PMID: 35005996). 35005996