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| Profile Name | BTK C481R BTK L528W |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BTK C481R BTK L528W | chronic lymphocytic leukemia | predicted - sensitive | NX-2127 | Case Reports/Case Series | Actionable | In a Phase I trial, NX-2127 treatment resulted in a partial response in a patient with chronic lymphocytic leukemia harboring BTK C481R and L528W, who had progressed on prior BTK inhibitors (PMID: 38301010; NCT04830137). | 38301010 |